Hemodynamic Improvement of Pulmonary Arterial Hypertension After Bariatric Surgery: Potential Role for Metabolic Regulation

Insulin resistance, metabolic syndrome, and adipokine dysregulation are now implicated in hypertensive pulmonary vascular disease (1–3). Even in nonobese humans with idiopathic pulmonary arterial hypertension (IPAH), the prevalence of insulin resistance is nearly 50% (1,2), suggesting a link between glucose dysregulation and IPAH. Additionally, IPAH develops spontaneously in animal models of obesity and adipokine alterations (4). The underlying mechanisms by which metabolic mediators exacerbate or cause pulmonary vascular disease are unknown.We tested the hypothesis that improvements in metabolic hormones are associated with amelioration of pulmonary hemodynamics in a 48-year-old morbidly obese female IPAH patient who underwent bariatric surgery. Despite no change in IPAH therapy, she had dramatic hemodynamic improvement coupled with reduced insulin resistance, plasma lipids, and cholesterol levels. The IPAH patient was New York Heart Association functional class III and desired bariatric surgery. After counseling about elevated surgical risk associated with anesthesia in IPAH patients, she underwent laparoscopic Roux-en-Y gastric bypass. Postoperative course was uncomplicated. She was stable on bosentan and sildenafil for 4 years preoperatively and postoperatively. The patient had mild obstructive sleep apnea and was compliant with therapy throughout her course. She did not have obesity hypoventilation syndrome or a diagnosis of diabetes preoperatively, and her peripheral oxygen saturation was normal preoperatively without supplemental oxygen. The patient’s BMI fell from 54 to 41 kg/m, and body fat fell from 57 to 31% over 20 months (Fig. 1). She reported improved exercise tolerance and became functional class II. Within 1 month of the procedure, before significant weight loss, right ventricular function improved by echocardiography (Fig. 1). Right heart catheterization 20 months after surgery (Fig. 1) demonstrated marked improvement, including elevation in cardiac output despite 43 kg weight loss. Plasma markers of insulin resistance (homeostasis model assessment of insulin resistance), lipids, and adipokines were measured at three points over 20 months. There was a drop in homeostasis model assessment of insulin resistance from 2.60 to 1.18. Free fatty acid levels fell from 1.27 to 0.86 mmol/L, LDL fell from 143.8 to 109.6 mg/dL, and HDL rose from 47 to 63 mg/dL and triglycerides from 56 to 67 mg/dL. Plasma adipokines demonstrated decreased leptin level from 39.49 to 29.25 ng/mL. Ghrelin, adiponectin, and resistin showed substantial variation in plasma levels over 20months. Weight loss and hemodynamic improvements correlated with reduction of insulin resistance, HDL, LDL, and free fatty acids. Although leptin dropped, there was no correlation between adiponectin, resistin, or ghrelin levels and hemodynamic improvement. This single patient represents an experiment in nature in which modest improvement in morbid obesity through bariatric surgery in IPAH correlated with marked rapid improvement in pulmonary vascular disease severity, despite no change in IPAH-directed therapy. These dramatic hemodynamic improvements are not seen either spontaneously in IPAH or as a response after several years of stable oral therapy. These data point to insulin resistance, lipid metabolism, and possibly, leptin as potential mediators of pulmonary vascular disease and suggest that adiponectin, ghrelin, and resistin may be less important to human IPAH development. This patient experience illustrates new potential pathways of importance in metabolic regulation that may have therapeutic potential for this devastating disease.